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Atorvastatin | Atorvastatin : Prodrug for HMGCR inhibitor
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

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Targets Biochemical/Biophysical Potency Cellular Potency
HMGCR
  • IC50:8 nM
  • Ki:6.2 nM
  • IC50:2.5 nM
up to 20 uM

Selectivity

Potency
Cellular
In Vitro

HMGCR

Mode of Action: Inhibitor, Prodrug

Structure-Activity-Relationship data available? No

DOI Reference: 10.1021/jm800001n

In Vivo Validations

Mouse
Dose: 10 mg/kg (IV), 300 mg/kg (PO)
Route of delivery: Intravenous, Oral
Systemic clearance: 48 ± 32 ml/min/Kg (IV, Blood)
Organ of interest (O): Liver

DOI Reference: 10.1021/jm800001n

Negative Control Compounds

3S, 5S-Atorvastatin
Notes: (3S, 5S)-Atorvastatin is an inactive or low-activity stereoisomeric enantiomer and pharmaceutical impurity (known as Atorvastatin EP Impurity E) of the cholesterol-lowering medication Atorvastatin.

Chemical Information

Molecular Formula C33H35FN2O5
SMILEs CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)O
InChI InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m1/s1
Molecular weight 558.25 Da
AlogP 6.313600000000008
HBond acceptors 7
HBond donors 4
Atoms 76

Vendors

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Expert Reviews

No SERP comments found for Atorvastatin

Probe Atorvastatin is in the process of SERP review.

Please continue to check back for new reviews and commentary.

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