From 9 am to 1 pm, twenty PhD students and postdoctoral researchers worked alongside seven expert reviewers at the 10th Chemical Probes Hackathon in Naples. Together they produced 16 new reviews for the Chemical Probes Portal, helping researchers worldwide identify high-quality chemical probes. Hosted by EUFEPS and SITELF, the event combined hands-on learning, scientific discussion, networking, and even authentic Italian espresso—earning enthusiastic feedback from participants.

The Chemical Probes Portal led a hands-on PROTAC Hackathon hosted at the Francis Crick Institute, bringing together 34 early-career researchers to critically evaluate chemical probes. Participants produced 24 structured reviews — soon to be featured on the Portal — and 100% reported improved understanding. The next Hackathon will take place at the Joint EUFEPS–SITELF Annual Meeting 2026 in Naples.

As we reflect on a landmark year for the Chemical Probes Portal, we celebrate major milestones in growth, community engagement, and a decade of impact. From expanding our collection of high-quality chemical probes and welcoming new expert reviewers, to record-breaking hackathons and ambitious plans for 2026, this newsletter highlights how the Portal continues to strengthen best practice and empower the global chemical biology community.