AK120413

Agonist of BRS3

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

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Information

BRS3

Agonist

up to 1 uM

Probe Availability:

MCULE

In Vitro Validations

Uniprot ID: P32247

Target Class: GPCR

Target SubClass: Bombesin receptor

Potency: IC50

Potency Value: 18.3 nM

Potency Assay: A competitive binding assay using radioligand and NFAT-CHO cell membranes. IC50 = 6.9 and 2.4 nM for mouse and rat homologs

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Bombesin receptor subtype-3, BRS3, BRS3_HUMAN, BRS ...

DOI Reference: 10.1016/j.bmcl.2010.02.076

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

∼1000-fold selectivity over hNMBR and hGRPR, the two most closely related GPCR

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 19 Aug 2022 )