AM-5262

Agonist of FFAR1

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(1 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Probe AM-5262 is in the process of SERP review.

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Information

FFAR1

Agonist

up to 1 uM

DOI - 10.1021/ml300427u

Probe Availability:

MCULE

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Panel screen data against 101 receptors: CEREP

Probe Selectivity in Vitro:

% of inhibition higher than 70% for 5/101: A3R_Human 97%; TXA2 synthetase_Human 88%; COX2_ACE 85%; CXCR2_Human 73%; COX1_ACE 71%

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 30 Nov 2021 )