AZD4144

AZD4144 : Inhibitor of NLRP3

Structure

SERP Rating

In Cells

(2 ratings)

In Model Organisms

(2 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Probe AZD4144 is in the process of SERP review.

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Information

NLRP3

Inhibitor

up to 1 uM

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

I have extra information to add

SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

Good cellular and in vivo tool compound for NLRP3. Additional activity data for rats, NLRP subfamily members, and a more general off target panel would be useful.

(last updated: 4 Dec 2025 )

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

When using the compound in vivo, evaluate several concentrations within the range of 0.3 to 10 mg/kg since it is not possible to determine which dose allowed 50% inhibition based on data plotted in the publication. Data for mice administered 0.3 to 10 mg/kg of the compound was presented as IL18 concentration versus unbound compound present in the plasma. Nevertheless, the compound works well in mouse studies.

(last updated: 18 Dec 2025 )