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BAY-885 | Inhibitor of MAPK7
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
MAPK7
  • IC50:35 nM
  • IC50:115 nM
Inhibitor
1 uM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Selectivity against Eurofins kinase panel at 1 μM (350 kinases were tested). Residual kinase activit ...

Potency
Cellular
In Vitro

MAPK7

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/acs.jmedchem.8b01606

Negative Control Compounds

BAY-693
Notes: BAY-693 with biochemical activity IC50 = 6.4 µM and cellular on target activity IC50 = 11 µM)

Orthogonal Probes def

AX15836
XMD8-92

Chemical Information

Molecular Formula C25H28F3N7O2
SMILEs CN1CCN(c2cnc3c(C4CCN(C(=O)c5ccc(OC(F)(F)F)cc5N)CC4)ncnc3c2)CC1
InChI InChI=1S/C25H28F3N7O2/c1-33-8-10-34(11-9-33)17-12-21-23(30-14-17)22(32-15-31-21)16-4-6-35(7-5-16)24(36)19-3-2-18(13-20(19)29)37-25(26,27)28/h2-3,12-16H,4-11,29H2,1H3
Molecular weight 515.23 Da
AlogP 3.2772000000000023
HBond acceptors 9
HBond donors 2
Atoms 65

Vendors

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Expert Reviews

by SERP
(on 22 May 2020)
Cellular Use Rating
BAY-885 is an excellent inhibitor of ERK5. It is potent, selective against other kinases and bromodomain-containing proteins, and active in cells. There is not an inactive close analogue that is commercially...
by SERP
(on 4 Jul 2020)
Cellular Use Rating
1 uM is a reasonable maximum concentration to ensure ERK5 inhibition while not perturbing many other kinases. However, care should be taken in phenotypic assays to rule out inhibition of FER and ephrin...
by SERP
(on 30 Jul 2020)
Cellular Use Rating
Key publication should be made public in a preprint server.
Note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Read more about our evaluation criteria