BI-113823

BI-113823 : Antagonist of BDKRB1

Structure

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Information

BDKRB1

Antagonist

100 nM

Additional Data

SGC image SGC Chemical Probe Collection

In Vitro Validations

Uniprot ID: P46663

Target Class: GPCR

Target SubClass: BK-1

Potency: Ki

Potency Value: 5.3 nM

Potency Assay: Radioligand binding assay (displacement of kallidin) at 10 µM

PDB ID for probe-target interaction (3D structure): --

Target aliases:

B1 bradykinin receptor, BRADYB1, BDKRB1, BKRB1_HUM ...

DOI Reference: 10.1371/journal.pone.0051151

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Selectivity within target family: Radioligand binding assay at 10 µM: hBDKRB2 Ki > 10 µM Selectivity outside target family: Eurofins SafteyScreen (69 targets) at 10 µM: Closest off-targets are SIGMAR1 (70 % inh.), TMEM97 (55 % inh.)

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