BI-1915

BI-1915 : Inhibitor of CTSS

Structure

SERP Rating

Probe BI-1915 is in the process of SERP review.

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Information

CTSS

Inhibitor

1 uM

Additional Data

SGC image SGC Chemical Probe Collection

In Vitro Validations

Uniprot ID: P25774

Target Class: Enzyme

Target SubClass: Peptidase

Potency: Kd

Potency Value: 31 nM

Potency Assay: SPR

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Cathepsin S, CTSS, CATS_HUMAN

DOI Reference: 10.1016/j.bmcl.2012.09.054

Uniprot ID: P25774

Target Class: Enzyme

Target SubClass: Peptidase

Potency: IC50

Potency Value: 17 nM

Potency Assay: Luminescent based enzymatic assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Cathepsin S, CTSS, CATS_HUMAN

DOI Reference: 10.1016/j.bmcl.2012.09.054

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay (off target): Selectivity within target family: IC50 [µM]: CTSK ( > 10) , CTSL ( > 30) , CTSB ( > 10) Reaction Biology protease panel (43) at 10 µM: clean, except for papain (87 % inhibition). Selectivity outside target family: Eurofins Cerep SafetyScreen44 at 10 µM: clean

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SERP ratings and comments

No SERP comments found for BI-1915