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BIBR-1532 | BIBR-1532 : Allosteric of TERT
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
TERT
  • IC50:93 nM
  • IC50:200 nM
  • IC50:67 ± 14 nM
  • IC50:~1 μM
Allosteric
up to 10 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
The selectivity profile for BIBR1532 was assessed in a panel of DNA and RNA polymerases. Enzymatic a ...

Potency
Cellular
In Vitro

TERT

Mode of Action: Allosteric

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1038/s41589-026-02238-6

In Vivo Validations

Mouse
Dose: 1 mg/Kg
Route of delivery: Intravenous
Volume of Distribution at Steady-State: 0.1 L/Kg
Target engagement assay: LD50 of 2000 mg/kg

DOI Reference: 10.1038/s41589-026-02238-6

Dose: 5 mg/Kg
Route of delivery: Oral
Plasma half life: 12.7 h
Area Under the Curve:: 140,761 ng*h/mL
Bioavailability: 80%

DOI Reference: 10.1038/s41589-026-02238-6

Negative Control Compounds

BIBR1654
Notes: The structurally related molecule BIBR1654 serves as a negative control with IC50 (hTERT) = 5 µM.

Orthogonal Probes def

BRACO19

Chemical Information

Molecular Formula C21H17NO3
SMILEs C/C(=C\C(=O)Nc1ccccc1C(=O)O)c1ccc2ccccc2c1
InChI InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+
Molecular weight 331.12 Da
AlogP 4.580000000000003
HBond acceptors 4
HBond donors 2
Atoms 42

References

Publications

Cross References

ChEMBL ChEMBL BindingDB PDB PubChem PubChem canSAR opnMe

Expert Reviews

No SERP comments found for BIBR-1532

Probe BIBR-1532 is in the process of SERP review.

Please continue to check back for new reviews and commentary.