BO-264

BO-264 : Inhibitor of TACC3

Structure

SERP Rating

Probe BO-264 is in the process of SERP review.

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Information

TACC3

Inhibitor

1 µM

Probe Availability:

In Vitro Validations

Uniprot ID: Q9Y6A5

Target Class: Motor Spindle Protein

Target SubClass: --

Potency: Kd

Potency Value: 1.5 nM

Potency Assay: ITC

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Transforming acidic coiled-coil-containing protein ...

DOI Reference: 10.1158/1535-7163.MCT-19-0957

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Cell:

Dose-response screen of the antiproliferative capacity of BO-264 in the NCI-60 human cancer cell line panel. BO-264 exhibited remarkable anticancer activity against more than 90% of the cell lines representing nine different subpanels with GI50 values less than 1 μmol/L.

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SERP ratings and comments

No SERP comments found for BO-264