CCT373566

CCT373566 : Molecular Glue for BCL6

Structure

SERP Rating

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Information

BCL6

Molecular Glues

up to 100 nM

In Vitro Validations

Uniprot ID: P41182

Target Class: Transcription factor

Target SubClass: Transcriptional Repressor

Potency: IC50

Potency Value: 2.2 nM

Potency Assay: TR-FRET

PDB ID for probe-target interaction (3D structure): 7QK0

Target aliases:

B-cell lymphoma 6 protein, ZNF51, ZBTB27, LAZ3, BC ...

DOI Reference: 10.1021/acs.jmedchem.1c02175

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Selectivity profiling of CCT373566 against kinases (468) and a safety panel (78) at 1 μM confirmed selective activity and minimal off-target interactions.

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