FHT-2344

FHT-2344 : Inhibitor of SMARCA2, SMARCA4 ATPase domains

Structure

SERP Rating

Probe FHT-2344 is in the process of SERP review.

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Information

SMARCA2
SMARCA4

Inhibitor

up to 1 uM

Additional Data

SGC image SGC Chemical Probe Collection

In Vitro Validations

Uniprot ID: P51531

Target Class: Epigenetic

Target SubClass: Bromodomain

Potency: IC50

Potency Value: 13.8 ± 3.3 nM

Potency Assay: ATPase catalytic activity using ADP-Glo™ detection

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Probable global transcription activator SNF2L2, SN ...

Other Reference: Peer reviewed at SGC

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Measurement of the ATPase catalytic activity using ADP-Glo™ detection reagent: CHD4 (IC50 > 200 μM, n= 4) KiNativ platform (ActivX): 200 ATPases tested in A375 cell lysates at 1 and 10 μM: clean

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SERP ratings and comments

No SERP comments found for FHT-2344