HSL-IN-1

HSL-IN-1 : Inhibitor of LIPE

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(1 ratings)

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Probe HSL-IN-1 is in the process of SERP review.

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Information

LIPE

Inhibitor

1 µM

Probe Availability:

In Vitro Validations

Uniprot ID: Q05469

Target Class: Enzyme

Target SubClass: Lipase

Potency: IC50

Potency Value: 2 nM

Potency Assay: In vitro colorimetric HSL assay using human HSL fractions and p-nitrophenyl butyrate (PNPB) as a substrate.

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Hormone-sensitive lipase, LIPE, LIPS_HUMAN, REH, H ...

DOI Reference: 10.1016/j.bmc.2017.02.045

In Cell Validations

No in Cell Validations available

In Vivo Data

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

The probe would benefit from selectivity profiling, especially, off-target activity on other serine hydrolases, including DAG-lipase, MAG-lipase, ABHD6, carboxylesterase. Activity-based protein profiling in relevant cell lines and tissue is required to obtain a view on its selectivity profile.

(last updated: 19 Oct 2022 )