JA397

JA397 : Inhibitor of CDK14, CDK15, CDK16, CDK17, CDK18 (TAIRE subfamily)

Structure

SERP Rating

In Cells

(2 ratings)

In Model Organisms

(0 ratings)

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Probe JA397 is in the process of SERP review.

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Information

CDK14
CDK15
CDK16
CDK17
CDK18

Inhibitor

up to 1 uM

Additional Data

SGC Chemical Probe Collection

In Vitro Validations

Uniprot ID: O94921

Target Class: Kinase

Target SubClass: CMGC

Potency: EC50

Potency Value: 27.1 nM

Potency Assay: NanoBRET in lysed cells

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Cyclin-dependent kinase 14, PFTK1, KIAA0834, CDK14 ...

DOI Reference: 10.3390/ijms232314834

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay (off target): Kinome-wide selectivity profile of JA397 was determined in in-house kinase DSF-panel comprising 105 kinases and at Reaction Biology at 1 µM comprising 340 WT kinases. Only CDK1, CDK9, and CDK10 were further off-targets inside the family but with weaker EC50 values of 581.9 nM, 993.4 nM, and 651.2 nM, respectively.

Potency assay, off target (cells): Selectivity within the CDK family was determined by NanoBRET.

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SERP ratings and comments

SERP Ratings

In Cell Rating

(last updated: 6 Mar 2024 )

SERP+ Ratings

In Cell Rating

(last updated: 23 Sept 2024 )