MK-3697

MK-3697 : Antagonist of HCRTR2

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(1 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Probe MK-3697 is in the process of SERP review.

Please continue to check back for new reviews and commentary.

Information

HCRTR2

Antagonist

up to 1 uM

Probe Availability:

In Vitro Validations

Uniprot ID: O43614

Target Class: GPCR

Target SubClass: Orexin receptor

Potency: Ki

Potency Value: 1.1 nM

Potency Assay: Radioligand Binding Assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Orexin receptor type 2, HCRTR2, OX2R_HUMAN, Ox2R, ...

DOI Reference: 10.1016/j.bmcl.2014.08.041

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Selective again OX1 both in vitro and in cells (Ki = 31 µM and IC50 > 10 µM, respectively)

I have extra information to add

SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 4 Jan 2024 )