ML075

ML075 : peptide competitive antagonist of NPY2R

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(1 ratings)

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Probe ML075 is in the process of SERP review.

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Information

NPY2R

peptide competitive

up to 1 µM

Probe Availability:

MCULE

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Selectivity within target family: selective over Y1R, IC50 >35 uM Selectivity outside target family: The selectivity of SF-11 was assessed by the NIMH PDSP, in which the compounds were screened for binding to receptors (n = 35), ion channels (n = 2), and transporters (n = 3) typically found in the CNS at 10 uM. Only DAT and 5HT2B showed >50% binding, further radioligand displacement assay excluded them as off-targets (7093 and 4989 nM respectively).

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

The maximum inhibitory effect of this compound looks like 80% or around based on the literature, the users may need to take into account this point.

(last updated: 2 Feb 2023 )