NVS-CECR2-1

NVS-CECR2-1 : Inhibitor of CECR2

Structure

SERP Rating

Probe NVS-CECR2-1 is in the process of SERP review.

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Information

CECR2

Inhibitor

up to 1 uM

Additional Data

SGC Chemical Probe Collection

In Vitro Validations

Uniprot ID: Q9BXF3

Target Class: Epigenetic

Target SubClass: Bromodomain

Potency: Kd

Potency Value: 80 nM

Potency Assay: ITC

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Chromatin remodeling regulator CECR2, KIAA1740, CE ...

DOI Reference: 10.1038/s41598-020-73500-7

Uniprot ID: Q9BXF3

Target Class: Epigenetic

Target SubClass: Bromodomain

Potency: IC50

Potency Value: 47 nM

Potency Assay: AlphaScreen

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Chromatin remodeling regulator CECR2, KIAA1740, CE ...

DOI Reference: 10.1038/s41598-020-73500-7

Uniprot ID: Q9BXF3

Target Class: Epigenetic

Target SubClass: Bromodomain

Potency: ΔTm

Potency Value: 12.52 °C

Potency Assay: Thermal shift

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Chromatin remodeling regulator CECR2, KIAA1740, CE ...

DOI Reference: 10.1038/s41598-020-73500-7

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay (off target): NVS-CECR2-1 shows no cross reactivity among bromodomains and no significant inhibition of protein kinases, proteases and receptors.

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SERP ratings and comments

No SERP comments found for NVS-CECR2-1