OICR11029

OICR11029 : Inhibitor of BCL6

Structure

SERP Rating

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Information

BCL6

Inhibitor

up to 1 uM

Additional Data

SGC Chemical Probe Collection

In Vitro Validations

Uniprot ID: P41182

Target Class: Transcriptional Factor

Target SubClass: Transcriptional Repressor

Potency: Kd

Potency Value: 10 nM

Potency Assay: SPR

PDB ID for probe-target interaction (3D structure): 7LZS

Target aliases:

B-cell lymphoma 6 protein, ZNF51, ZBTB27, LAZ3, BC ...

DOI Reference: 10.1021/acsmedchemlett.2c00502

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Selective against other BTB domains: BAZF (BCL6B) 1.40 uM, FAZF, PLZF, Miz1, Kaiso, LRF > 10 uM. Outside target family: OICR11029 Eurofin’s kinase profiling at 3 uM, no inhibition above 50% of any of the 468 kinases. OICR11029 was assessed in the Eurofins CEREP Safety panel of at 10 uM concentration; Only 1/53 >50%; MT1 agonist inhibition at 10 μM

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SERP ratings and comments

No SERP comments found for OICR11029