PF-04418948

Antagonist of PTGER2

Structure

SERP Rating

Probe PF-04418948 is in the process of SERP review.

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Information

PTGER2

Antagonist

< 300 nM

Additional Data

SGC image SGC Chemical Probe Collection

Probe Availability:

In Vitro Validations

Uniprot ID: P43116

Target Class: GPCR

Target SubClass: Prostaglandin E Receptor 2

Potency: IC50

Potency Value: 5 nM

Potency Assay: Inhibition of binding to PTGER2

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Prostaglandin E2 receptor EP2 subtype, PTGER2, PE2 ...

DOI Reference: 10.1111/j.1476-5381.2011.01495.x

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): No agonist activity is observed across the family. Clean GPCR scan.

Probe Selectivity in Vitro:

With the exception of LTB4R (960 fold), MT3 (104 fold) and PDE3A (700 fold), no significant off-target pharmacology in CEREP wide-ligand profiling at 10 μM. Antagonist activity: IC50 = 16 nM.

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SERP ratings and comments

No SERP comments found for PF-04418948