PF-06471553

PF-06471553 : Inhibitor of MOGAT3

Structure

SERP Rating

Probe PF-06471553 is in the process of SERP review.

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Information

MOGAT3

Inhibitor

up to 10 uM

Probe Availability:

In Vitro Validations

Uniprot ID: Q86VF5

Target Class: Enzyme

Target SubClass: Acyltransferase

Potency: IC50

Potency Value: 92 nM

Potency Assay: Biochemical quantification of radioactive product assessing its DGAT activity.

PDB ID for probe-target interaction (3D structure): --

Target aliases:

2-acylglycerol O-acyltransferase 3, DGAT2L7, DC7, ...

DOI Reference: 10.1021/acs.jmedchem.5b01008

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

PF-06471553 @ 10 μM was selective against a broad panel of more than 120 individual targets, including various transporters, receptors, ion channels, and enzymes. More than >160 fold in vitro selectivity for MGAT3 over DGAT1, DGAT2, MGAT1, and MGAT2: MGAT1 (14.9 µM), MGAT2 (19.8 µM), DGAT1 (>50 µM) and DGAT2 (>100 µM).

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SERP ratings and comments

No SERP comments found for PF-06471553