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Rociletinib | Covalent Inhibitor of EGFR (Mutant:L858R/T790M)
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

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Targets Biochemical/Biophysical Potency Cellular Potency
EGFR (Mutant:L858R/T790M)
  • Ki:21.5 nM L858R/T790M; 303.3 nM WT
  • IC50:62-187 nM
Covalent Inhibitor
100 - 1000 nM

Selectivity

In Vitro Selectivity Assessment
Selectivity Assessment Description:
Rociletinib selectivity was tested against 434 kinases in duplicate at a concentration of 0.1μM a ...

Potency
Cellular
In Vitro

EGFR (Mutant:L858R/T790M)

Mode of Action: Covalent Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1158/1535-7163.MCT-13-0966

In Vivo Validations

Mouse
Dose: 3-100 mg/Kg
Route of delivery: Oral
Plasma half life: 2.6 h

DOI Reference: 10.1158/1535-7163.MCT-13-0966

Orthogonal Probes def

WZ4002

Chemical Information

Molecular Formula C27H28F3N7O3
SMILEs C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3OC)ncc2C(F)(F)F)c1
InChI InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
Molecular weight 555.22 Da
AlogP 4.784200000000004
HBond acceptors 10
HBond donors 3
Atoms 68

Vendors

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Expert Reviews

by SERP+
(on 9 Jul 2026)
Cellular Use Rating
In Model Organisms
Rociletinib appears to be a selective inhibitor of EGFR mutants (L858R/T790) with an IC50 of 0.5 nM. After incubation of this compound with cells (and washout of excess compound) 50% of protein activity...
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