RW-78

RW-78 : Inhibitor of SIRT2

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(0 ratings)

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Probe RW-78 is in the process of SERP review.

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Information

SIRT2

Inhibitor

1 µM

In Vitro Validations

Uniprot ID: Q8IXJ6

Target Class: Epigenetic

Target SubClass: HDAC (Class III)

Potency: IC50

Potency Value: 26 nM

Potency Assay: Standard fluorescence-based assay.

PDB ID for probe-target interaction (3D structure): 9S46

Target aliases:

NAD-dependent protein deacetylase sirtuin-2, SIR2L ...

DOI Reference: 10.1039/D5MD00144G

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Subtype selective towards SIRT2. IC50 values for SIRT1, 3 and 5 are above 50 µM

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SERP ratings and comments

SERP Ratings

In Cell Rating

SERP Comments:

RW-78 is a potent and subtype selective SIRT2 probe that displaces the NAD+ co-factor. It showed high target engagement in HEK293T cells via NanoBRET assay. Solubility: > 50 μM (Tris-HCl, pH = 8, final DMSO concentration of 5% (v/v)), no stability and assay interference data were reported.

(last updated: 23 Feb 2026 )