SC-560

Inhibitor of PTGS1

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(1 ratings)

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Probe SC-560 is in the process of SERP review.

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Information

PTGS1

Inhibitor

300 nM

Probe Availability:

In Vitro Validations

Uniprot ID: P23219

Target Class: Enzyme

Target SubClass: Synthase

Potency: IC50

Potency Value: 9 nM

Potency Assay: Biochemical assay using recombinant COX-1 and arachidonic acid

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Prostaglandin G/H synthase 1, COX1, PTGS1, PGH1_HU ...

DOI Reference: 10.1073/pnas.95.22.13313

In Cell Validations

No in Cell Validations available

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Selective against COX-2 with IC50 6.3 μM and more than 40% of remaining COX-2 activity at concentrations up to 100 μM.

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

This is for sure a very suitable COX probe.

(last updated: 2 Jan 2023 )