Selexipag

Selexipag : Agonist of PTGIR

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(1 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Probe Selexipag is in the process of SERP review.

Please continue to check back for new reviews and commentary.

Information

PTGIR

Agonist

up to 1 uM

In Vitro Validations

Uniprot ID: P43119

Target Class: GPCR

Target SubClass: Prostacyclin receptor

Potency: IC50

Potency Value: 200 nM

Potency Assay: Inhibition of platelet aggregation induced by ADP (10 μM) in human platelet rich plasma

PDB ID for probe-target interaction (3D structure): 8X79

Target aliases:

Prostacyclin receptor, PRIPR, PTGIR, PI2R_HUMAN, P ...

DOI Reference: 10.1021/acs.jmedchem.5b00698

Uniprot ID: P43119

Target Class: GPCR

Target SubClass: Prostacyclin receptor

Potency: Ki

Potency Value: 20 nM

Potency Assay: Biochemical assay

PDB ID for probe-target interaction (3D structure): 8X79

Target aliases:

Prostacyclin receptor, PRIPR, PTGIR, PI2R_HUMAN, P ...

DOI Reference: 10.1021/acs.jmedchem.5b00698

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Compound 12b binds other prostanoid receptors with at least 130-fold lower affinity.

I have extra information to add

SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 6 May 2025 )