T-690

T-690 : Inhibitor of UGCG

Structure

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Probe T-690 is in the process of SERP review.

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Information

UGCG

Inhibitor

up to 1 uM

Probe Availability:

MedChemExpress

In Vitro Validations

Uniprot ID: Q16739

Target Class: Enzyme

Target SubClass: Glycosyltransferase

Potency: IC50

Potency Value: 15 nM

Potency Assay: GCS enzymatic assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Ceramide glucosyltransferase, UGCG, CEGT_HUMAN, GC ...

DOI Reference: 10.1021/acs.jmedchem.1c02078

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): SAFETYscan (DiscoverX (Eurofins) 47 targets at 10 µM): 44 target > 10 µM; HTR1B (EC50 = 1.5 μM), nAChR(a4/b2) Blocker (CHRNA4) (IC50 = 1.4 μM); T-690 has no SERT inhibitory activity (IC50 > 10 μM), which was the representative off-target activity of its parent compound T-036

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(last updated: 19 Nov 2023 )