TES-1025

TES-1025 : Inhibitor of ACMSD

Structure

SERP Rating

Probe TES-1025 is in the process of SERP review.

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Information

ACMSD

Inhibitor

5 uM

Probe Availability:

MedChemExpress

In Vitro Validations

Uniprot ID: Q8TDX5

Target Class: Enzyme

Target SubClass: Carboxylase

Potency: IC50

Potency Value: 13 ± 3 nM

Potency Assay: ACMSD enzymatic assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

2-amino-3-carboxymuconate-6-semialdehyde decarboxy ...

DOI Reference: 10.1021/acs.jmedchem.7b01254

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Activity on a panel of nuclear receptors: PXR, PPARs, LXR, VDR, GR, RXR, FXR, TR, was based on Alpha Technology (PerkinElmer). Off-Target Safety Panel The GPCR, ion channel, kinase, and phosphatase assays were Eurofins GPCRProfiler, IonChannelProfiler, KinaseProfiler, and PhosphataseProfiler Services.

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No SERP comments found for TES-1025