TNO155

TNO155 : Allosteric of PTPN11

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(1 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Probe TNO155 is in the process of SERP review.

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Information

PTPN11

Allosteric

up to 1 uM

Probe Availability:

In Vitro Validations

Uniprot ID: Q06124

Target Class: Enzyme

Target SubClass: Protein-tyrosine phosphatase

Potency: IC50

Potency Value: 11 nM

Potency Assay: Biochemical DiFMUP Assay

PDB ID for probe-target interaction (3D structure): 7JVM

Target aliases:

Tyrosine-protein phosphatase non-receptor type 11, ...

DOI Reference: 10.1021/acs.jmedchem.0c01170

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Completely selective over panels of phosphatases and kinases based on screening in commercial panels

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

TNO155 has an interesting mechanism-of-action, acting at a key allosteric site to block SHP2 activity. It is recommended for use in studying this phosphatase, especially in combination with other inhibitors targeting the pathway.

(last updated: 8 Nov 2022 )