TP-040

TP-040 : Inhibitor of OGA

Structure

SERP Rating

Probe TP-040 is in the process of SERP review.

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Information

Inhibitor

up to 10 uM

Additional Data

SGC image SGC Chemical Probe Collection

Probe Availability:

MCULE

In Vitro Validations

Uniprot ID: O60502

Target Class: Enzyme

Target SubClass: Hydrolase

Potency: IC50

Potency Value: 46 nM

Potency Assay: Human OGA enzymatic assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Protein O-GlcNAcase, MGEA5, MEA5, KIAA0679, HEXC, ...

DOI Reference: 10.1021/acs.jmedchem.0c01712

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Selectivity within target family - HEXB IC50 > 10 µM (> 210-fold). Selectivity outside target family - Kinase panel (277 kinases at 1 µM): clean, all < 50 % inhibition.

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SERP ratings and comments

No SERP comments found for TP-040