ML216
ML216
Structure
This is unsuitable as a chemical probe: While this
compound has been used to interrogate specific protein
targets, it is not a chemical probe and should not be used
in assays that depend on a potent and selective modulator
of the protein.
Unsuitable
Intended target: WRN helicase
A 2024 publication by Heuser A. et al reports that previously published WRN Helicase inhibitors (ML216, NSC19630 or NSC617145) have now been characterised by an extensive set of biochemical and biophysical assays and have been ruled out as specific WRN helicase probes. DOI: 10.1002/cmdc.202300613