YKL-05-099

YKL-05-099 : Inhibitor of SIK1, SIK3, SIK2

Structure

SERP Rating

Probe YKL-05-099 is in the process of SERP review.

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Information

SIK1
SIK3
SIK2

Inhibitor

up to 1 µM

In Vitro Validations

Uniprot ID: P57059

Target Class: Kinase

Target SubClass: CAMK

Potency: IC50

Potency Value: 10.9 nM

Potency Assay: Competitive binding assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Serine/threonine-protein kinase SIK1, SNF1LK, SIK, ...

DOI Reference: 10.1021/acschembio.6b00217

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): YKL-05-099 (1 μM) was tested for its ability to inhibit the activity of 144 kinases at the MRC PPU International Center for kinase profiling. In addition, YKL-05-099 (1 μM) was tested for interaction with 468 recombinant kinases using the KINOMEscan active site-directed competitive binding assay (DiscoverRx).

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